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10 Granulators - Pharmaceutical For Sale

Featured Granulators - Pharmaceutical

Used Pharmaceutical Granulators

Outside of the pharmaceutical industry, granulators are rotating grinders that are used to scrape scrap parts and melt delivery systems into feedstock sized granules for  reuse. In the pharmaceutical world, granulation is one of the more important processes in the production of drugs and medicines as the granules that are produced are used directly as drugs or serve as an intermediate product in the manufacture of tablets or capsules.

Over 60% of pharmaceutical products are produced as tablets, capsules, or similar. Because of this, granulation systems play an extremely important role in producing tablets by efficiently granulating powder-like particles. Aaron Equipment carries several granulators including high shear and oscillating non-plastic granulators. High shear granulators are used for shaping processes in the pharmaceutical industry. This happens in a closed container with blending tools and creates a denser granulate than the fluidized bed process. From there, a dosed distribution using a spray nozzle is used to obtain an even granulate. Oscillating granulators are used for slightly gentle homogenization, size reduction, grading and sieving of powders and granules in pharmaceutical, chemical and food industries. In use, the product is charged from the top through a feed hopper and the material falls on rotor blades at the bottom. Through this process, the particle downsizes and gets pushed outward from an opening at the bottom. If you are looking to sell your used oscillating granulators submit a request online or contact Erik Eichert at 630-238-7480.

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Everything You Should Know Before Buying Used Pharmaceutical Granulators

Your Guide To Exploring Pharmaceutical Granulators: New vs. Used
Pharmaceutical granulators are essential in the manufacturing process. They help convert powders into granules for tablets and capsules. Understanding their types can significantly impact product quality. This guide will explore the differences between new and used pharmaceutical granulators and discuss the key processes involved: wet granulation and dry granulation. By the end, you'll know how to make informed decisions about your pharmaceutical machinery needs. Let's dive into the world of granulation.

What Are Pharmaceutical Granulators?
Pharmaceutical granulators are specialized machines used to form granules from powdered substances. The granulation process is a fundamental step in pharmaceutical manufacturing, ensuring that the final product is consistent in size and composition. Granulation helps improve the ingredients' flowability, compressibility, and uniformity, which are critical for producing high-quality pharmaceuticals. High shear and oscillating granulators are two common types of pharmaceutical granulators used in both wet and dry granulation processes. Pharmaceutical granulators can be a small laboratory-scale granulator for pharmaceutical R&D purposes or a rapid mixer granulator for high-volume drug manufacturing.

Types of Granulation Processes
Granulation processes can generally be categorized into two main types: wet and dry. Each process has its distinct methods and applications in the pharmaceutical industry.

  • Wet Granulation: Wet granulation involves using a liquid binder to agglomerate powder particles into granules. This process is widely used because it improves the powder mix's compressibility and flow properties.
    • High-Shear Granulators: High-shear granulators are commonly used for wet granulation. They consist of a mixing bowl, an impeller, and a chopper. The impeller mixes the powder while the chopper breaks down any lumps, ensuring uniform granule size.
    • Fluid Bed Granulators: Fluid bed granulators utilize a fluidizing air stream to agitate and suspend the powder particles. The binding solution is sprayed onto the fluidized powder, resulting in granules. This method is known for its efficiency in simultaneously drying and granulating.
    • Application use case:  
      • Continuous twin-screw wet granulation for pharmaceuticals

  • Dry Granulation: Dry granulation does not require a liquid binder. Instead, it uses pressure to compact the powder mix into dense sheets or slugs, which are then broken down into granules. This process is suitable for moisture-sensitive materials or those that degrade upon exposure to liquid.
    • Roller Compactors: Roller compactors are the primary equipment used in dry granulation. They consist of two counter-rotating rollers that compact the powder into sheets, then milled into granules.
    • Slugging involves compressing the powder into large tablets or slugs using a tablet press. These slugs are then broken down into granules utilizing a milling machine.
    • Application use case:  
      • High shear mixer granulator for tablet production
      • Fluid bed processor for pharmaceutical granulation
      • Roller compactor for dry granulation of pharmaceuticals

Choosing Between New and Used Pharmaceutical Granulators
Several factors, including cost, condition, and technological advancements, must be considered when deciding between new and used pharmaceutical granulators.

  • Advantages of New Granulators
    • Latest Technology: New granulators are equipped with the latest technology, which often translates to better efficiency, precision, and control over the granulation process.
    • Warranty and Support: Purchasing new machinery usually comes with a warranty and customer support, providing peace of mind and assistance in case of any issues.
    • Customization: New machines can be customized to meet specific manufacturing requirements, ensuring optimal performance for unique production needs.
  • Benefits of Used Granulators
    • Cost-Effectiveness: Used granulators are typically more affordable than new ones, making them a viable option for businesses with budget constraints. 
    • Immediate Availability: Used equipment is often available for immediate purchase and installation, which can be advantageous for companies needing to scale up production quickly. 
    • Proven Reliability: Many used granulators have a track record of performance, giving buyers confidence in their reliability and functionality.

Key Considerations When Purchasing a Granulator
When selecting a new or used granulator, several factors must be assessed to ensure it meets your production needs.

  • Capacity and Throughput: Determine the production capacity and throughput requirements of your pharmaceutical manufacturing process. Choose a granulator that can handle the desired volume efficiently without compromising quality.
  • Material Compatibility: Ensure that the granulator is compatible with the materials you will be processing. Different materials may require specific types of granulators or settings to achieve optimal results.
  • Maintenance and Upkeep: Consider the granulator's maintenance requirements. Machines that are easy to clean and maintain can reduce downtime and enhance productivity in the long run.

The Role of Granulators in Pharmaceutical Manufacturing
Pharmaceutical granulators are crucial in ensuring the uniformity, stability, and quality of pharmaceutical products. They enhance the flowability and compressibility of powders, making them easier to handle and process. Additionally, granulators help achieve consistent dosing, which is vital for patient safety and medication efficacy.

Top Pharmaceutical Granulator Brands
While there are many reputable manufacturers, the US market has shown a preference for the following brands:

  • GEA, Glatt, Freund-Vector and many more!

Understanding the types and functionalities of pharmaceutical granulators is essential for making informed purchasing decisions. Whether you opt for a new or used granulator, consider capacity, material compatibility, and maintenance requirements to ensure it aligns with your manufacturing needs. Choosing the proper granulator can enhance your production efficiency and maintain the high standards required in pharmaceutical manufacturing. With this guide, you're now equipped with the knowledge to navigate the world of pharmaceutical granulators confidently.

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